MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment

@inproceedings{Domnitz2012MCAKAA,
  title={MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment},
  author={Sarah B. Domnitz and Michael J. Wagenbach and Justin Decarreau and Linda Wordeman},
  booktitle={The Journal of cell biology},
  year={2012}
}
Mitotic centromere-associated kinesin (MCAK) is a microtubule-depolymerizing kinesin-13 member that can track with polymerizing microtubule tips (hereafter referred to as tip tracking) during both interphase and mitosis. MCAK tracks with microtubule tips by binding to end-binding proteins (EBs) through the microtubule tip localization signal SKIP, which lies N terminal to MCAK's neck and motor domain. The functional significance of MCAK's tip-tracking behavior during mitosis has never been… CONTINUE READING
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