MC3T3-E1 osteoprogenitor cells systemically migrate to a bone defect and enhance bone healing.

@article{Gibon2012MC3T3E1OC,
  title={MC3T3-E1 osteoprogenitor cells systemically migrate to a bone defect and enhance bone healing.},
  author={Emmanuel Gibon and Barbara Batke and Muhammad Umar Jawad and Kate E Fritton and Allison J. Rao and Zhenyu Yao and Sandip Biswal and Sanjiv Sam Gambhir and Stuart B Goodman},
  journal={Tissue engineering. Part A},
  year={2012},
  volume={18 9-10},
  pages={968-73}
}
Although iliac crest autologous bone graft remains the gold standard for treatment of bone defects, delayed- and nonunions, and arthrodeses, several alternative strategies have been attempted, including the use of mesenchymal stem cells. Whether cells from the osteoblast lineage demonstrate systemic recruitment to an acute bone defect or fracture, and whether these cells directly participate in bone healing is controversial. This study tests two hypotheses: (1) that exogenous murine MC3T3-E1… CONTINUE READING
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