MC1R variants, melanoma and red hair color phenotype: a meta-analysis.

  title={MC1R variants, melanoma and red hair color phenotype: a meta-analysis.},
  author={Sara Raimondi and Francesco Sera and Sara Gandini and Simona Iodice and Saverio Caini and Patrick Maisonneuve and Maria Concetta Fargnoli},
  journal={International journal of cancer},
  volume={122 12},
Melanocortin-1-receptor (MC1R) is one of the major genes that determine skin pigmentation. MC1R variants were suggested to be associated with red hair, fair skin, and an increased risk of melanoma. We performed a meta-analysis on the association between the 9 most studied MC1R variants (p.V60L, p.D84E, p.V92M, p.R142H, p.R151C, p.I155T, p.R160W, p.R163Q and p.D294H) and melanoma and/or red hair, fair skin phenotype. Eleven studies on MC1R and melanoma, and 9 on MC1R and phenotype were included… CONTINUE READING
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