MC1R and the response of melanocytes to ultraviolet radiation.

  title={MC1R and the response of melanocytes to ultraviolet radiation.},
  author={François Rouzaud and Ana Luisa Kadekaro and Zalfa A Abdel-Malek and Vincent J. Hearing},
  journal={Mutation research},
  volume={571 1-2},
The constitutive color of our skin plays a dramatic role in our photoprotection from solar ultraviolet radiation (UVR) that reaches the Earth and in minimizing DNA damage that gives rise to skin cancer. More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the melanocortin 1 receptor (MC1R), a seven-transmembrane G protein-coupled receptor expressed on the surface of melanocytes. Modulation of MC1R… CONTINUE READING
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