MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.

@article{Sjolund2013MBD4AT,
  title={MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.},
  author={Ashley Brooke Sjolund and Alireza Ghodsi Senejani and Joann Balazs Sweasy},
  journal={Mutation research},
  year={2013},
  volume={743-744},
  pages={12-25}
}
The base excision repair system is vital to the repair of endogenous and exogenous DNA damage. This pathway is initiated by one of several DNA glycosylases that recognizes and excises specific DNA lesions in a coordinated fashion. Methyl-CpG Domain Protein 4 (MBD4) and Thymine DNA Glycosylase (TDG) are the two major G:T glycosylases that remove thymine generated by the deamination of 5-methylcytosine. Both of these glycosylases also remove a variety of other base lesions, including G:U and… CONTINUE READING
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