MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

@article{Jiang2002MBD3L1AM,
  title={MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.},
  author={Chun Ling Jiang and Seung Gi Jin and Dong Hyun Lee and Zi Jian Lan and Xueping Xu and Timothy R. O'Connor and Piroska E. Szab{\'o} and Jeffrey R. Mann and Austin John Cooney and Gerd. P. Pfeifer},
  journal={Genomics},
  year={2002},
  volume={80 6},
  pages={621-9}
}
Methylation of cytosines at CpG dinucleotides is essential for mammalian development. MeCP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of proteins that contain a methyl-CpG binding domain (MBD). Except for MBD4, these proteins are involved in gene silencing imposed by methylated DNA. We have identified a human gene that codes for a protein that is 42% identical to MBD3 and 38% identical to MBD2 but lacks the methyl-CpG binding domain. The recombinant protein does not bind to methylated DNA… CONTINUE READING
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