MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

@article{Morey2008MBD3AC,
  title={MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.},
  author={Lluis Morey and Carmen Brenner and Francesco Fazi and Raffaella Villa and Arantxa Guti{\'e}rrez and Marcus Buschbeck and Clara Nervi and Saverio Minucci and François Fuks and Luciano Di Croce},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 19},
  pages={5912-23}
}
In plants, as in mammals, mutations in SNF2-like DNA helicases/ATPases were shown to affect not only chromatin structure but also global methylation patterns, suggesting a potential functional link between chromatin structure and epigenetic marks. The SNF2-like ATPase containing nucleosome remodeling and deacetylase corepressor complex (NuRD) is involved in gene transcriptional repression and chromatin remodeling. We have previously shown that the leukemogenic protein PML-RARa represses target… CONTINUE READING
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