MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells.

@article{Takaki2014MAVSdependentIB,
  title={MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells.},
  author={Hiromi Takaki and Kenya Honda and Koji Atarashi and F. Kobayashi and Takashi Ebihara and Hiroyuki Oshiumi and Misako Matsumoto and Masashi Shingai and Tsukasa Seya},
  journal={Molecular immunology},
  year={2014},
  volume={57 2},
  pages={100-10}
}
Measles virus (MV) infects CD150Tg/Ifnar (IFN alpha receptor)(-/-) mice but not CD150 (a human MV receptor)-transgenic (Tg) mice. We have shown that bone marrow-derived dendritic cells (BMDCs) from CD150Tg/Ifnar(-/-) mice are permissive to MV in contrast to those from simple CD150Tg mice, which reveals a crucial role of type I interferon (IFN) in natural tropism against MV. Yet, the mechanism whereby BMDCs produce initial type I IFN has not been elucidated in MV infection. RNA virus infection… CONTINUE READING

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