MATE1 has an external COOH terminus, consistent with a 13-helix topology.

@article{Zhang2009MATE1HA,
  title={MATE1 has an external COOH terminus, consistent with a 13-helix topology.},
  author={Xiaohong Mary Zhang and Stephen H. Wright},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={297 2},
  pages={F263-71}
}
The mammalian members of the Multidrug And Toxin Extruder family, i.e., MATE1 and MATE2-K, are suspected of mediating the luminal step in renal secretion of organic cations. The 1,000+ prokaryotic/fungal/plant MATE family members are predicted to have 12 transmembrane helices (TMHs), whereas MATE1/2-K appear to have an additional (13th) COOH-terminal helix. Here, we determined whether rabbit MATE1 has an external COOH terminus, consistent with the presence of 13 TMHs. A V5 epitope tag at the… CONTINUE READING

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