MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.

@article{Peng2013MAT2BGIT1IA,
  title={MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.},
  author={Hui Peng and Lily Dara and Tony W.H. Li and Yuhua Zheng and Heping Yang and Maria Lauda Tomasi and Ivan Tomasi and Pasquale Giordano and Jose M. Mato and Shelly C. Lu},
  journal={Hepatology},
  year={2013},
  volume={57 6},
  pages={2299-313}
}
UNLABELLED Methionine adenosyltransferase 2B (MAT2B) encodes for two variant proteins (V1 and V2) that promote cell growth. Using in-solution proteomics, GIT1 (G Protein Coupled Receptor Kinase Interacting ArfGAP 1) was identified as a potential interacting partner of MAT2B. Here, we examined the functional significance of this interplay. Coimmunoprecipitation experiments examined protein interactions. Tissue expression levels of proteins were examined using immunohistochemistry and western… CONTINUE READING
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