MASPIC: intensity-based tandem mass spectrometry scoring scheme that improves peptide identification at high confidence.

@article{Narasimhan2005MASPICIT,
  title={MASPIC: intensity-based tandem mass spectrometry scoring scheme that improves peptide identification at high confidence.},
  author={Chandrasegaran Narasimhan and David L. Tabb and Nathan Verberkmoes and Melissa R Thompson and Robert L. Hettich and Edward C. Uberbacher},
  journal={Analytical chemistry},
  year={2005},
  volume={77 23},
  pages={7581-93}
}
Algorithmic search engines bridge the gap between large tandem mass spectrometry data sets and the identification of proteins associated with biological samples. Improvements in these tools can greatly enhance biological discovery. We present a new scoring scheme for comparing tandem mass spectra with a protein sequence database. The MASPIC (Multinomial Algorithm for Spectral Profile-based Intensity Comparison) scorer converts an experimental tandem mass spectrum into a m/z profile of… CONTINUE READING