MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans.

  title={MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans.},
  author={Ming Zhang and Yunfang Joan Hou and Erdal Cavuşoğlu and Daniel C. Lee and Rudi M Steffensen and Liming Yang and Daniel R. Bashari and Jose Villamil and Motaz Moussa and George A Fernaine and Jens Christain Jensenius and Jonathan D. Marmur and Wilson Ko and Ketan Shevde},
  journal={International journal of cardiology},
  volume={166 2},
BACKGROUND/OBJECTIVES Insufficient blood supply to the heart results in ischemic injury manifested clinically as myocardial infarction (MI). Following ischemia, inflammation is provoked and related to the clinical outcomes. A recent basic science study indicates that complement factor MASP-2 plays an important role in animal models of ischemia/reperfusion injury. We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart… CONTINUE READING
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