MARF1 regulates essential oogenic processes in mice.

@article{Su2012MARF1RE,
  title={MARF1 regulates essential oogenic processes in mice.},
  author={You-Qiang Su and Koji Sugiura and Fengyun Sun and Janice K Pendola and Gregory A. Cox and Mary Ann Handel and John C. Schimenti and John J. Eppig},
  journal={Science},
  year={2012},
  volume={335 6075},
  pages={1496-9}
}
Development of fertilization-competent oocytes depends on integrated processes controlling meiosis, cytoplasmic development, and maintenance of genomic integrity. We show that meiosis arrest female 1 (MARF1) is required for these processes in mammalian oocytes. Mutations of Marf1 cause female infertility characterized by up-regulation of a cohort of transcripts, increased retrotransposon expression, defective cytoplasmic maturation, and meiotic arrest. Up-regulation of protein phosphatase 2… CONTINUE READING

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We thank M

  • O. H. Tam et al., Nature 453, 534 . Acknowledgments
  • Conti for providing the Cdc25b plasmid and Gpr3…
  • 1985

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