MARCKS regulation of mucin secretion by airway epithelium in vitro: interaction with chaperones.

@article{Park2008MARCKSRO,
  title={MARCKS regulation of mucin secretion by airway epithelium in vitro: interaction with chaperones.},
  author={Joungjoa Park and Shijing Fang and Anne L. Crews and Ko-Wei Lin and Kenneth B. Adler},
  journal={American journal of respiratory cell and molecular biology},
  year={2008},
  volume={39 1},
  pages={
          68-76
        }
}
We have reported previously that myristoylated alanine-rich C kinase substrate (MARCKS) is a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. The results of those studies supported a mechanism whereby MARCKS, upon phosphorylation by protein kinase C (PKC), translocates from plasma membrane to cytoplasm, where its binding to membranes of intracellular mucin granules is a key component of the secretory pathway. It remains unknown how MARCKS is… CONTINUE READING

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