MARCKS: a case of molecular exaptation?

@article{Ramsden2000MARCKSAC,
  title={MARCKS: a case of molecular exaptation?},
  author={Jeremy J. Ramsden},
  journal={The international journal of biochemistry & cell biology},
  year={2000},
  volume={32 5},
  pages={
          475-9
        }
}
  • Jeremy J. Ramsden
  • Published 2000 in
    The international journal of biochemistry & cell…
MARCKS (myristoylated alanine-rich C kinase substrate, 32 kDa) and its 20 kDa brother MARCKS-related protein (MRP) are abundant, widely distributed proteins unusually rich in alanine and glutamic acid, and with lysines, serines and phenylalanines concentrated in a compact "effector domain" (ED) near the middle of the sequence. Its conformation in solution appears to be labile, with little evidence for definite secondary structure. MARCKS (and MRP) interact inter alia with lipid bilayer… CONTINUE READING
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