MAR Elements and Transposons for Improved Transgene Integration and Expression

  title={MAR Elements and Transposons for Improved Transgene Integration and Expression},
  author={D{\'e}borah Ley and Niamh Harraghy and Val{\'e}rie Le Fourn and Solenne Bire and P. Girod and Alexandre Regamey and Florence Rouleux-Bonnin and Yves Bigot and Nicolas Mermod},
  booktitle={PloS one},
Reliable and long-term expression of transgenes remain significant challenges for gene therapy and biotechnology applications, especially when antibiotic selection procedures are not applicable. In this context, transposons represent attractive gene transfer vectors because of their ability to promote efficient genomic integration in a variety of mammalian cell types. However, expression from genome-integrating vectors may be inhibited by variable gene transcription and/or silencing events. In… CONTINUE READING
Highly Cited
This paper has 166 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 13 extracted citations

166 Citations

Citations per Year
Semantic Scholar estimates that this publication has 166 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…