MAPs, MARKs and microtubule dynamics.

  title={MAPs, MARKs and microtubule dynamics.},
  author={Gerard Drewes and Andreas Ebneth and Eckhard Mandelkow},
  journal={Trends in biochemical sciences},
  volume={23 8},
Microtubules (MTs) serve as tracks for cellular transport, and regulate cell shape and polarity. Rapid transitions between stable and dynamic forms of MTs are central to these processes. This dynamic instability is regulated by a number of cellular factors, including the structural MT-associated proteins (MAPs), which in turn are regulated by phosphorylation. MT-affinity-regulating kinases (MARKs) are novel mammalian serine/threonine kinases that phosphorylate the tubulin-binding domain of MAPs… CONTINUE READING


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