MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas.

  title={MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas.},
  author={Ayumu Taguchi and Jung-hyun Rho and Qingxiang Yan and Yuzheng Zhang and Yang Zhao and Hanwen Xu and Satyendra C Tripathi and Hong Wang and Dean E. Brenner and Melanie Kucherlapati and Raju Kucherlapati and Adam T. Boutin and Y. Alan Wang and Ronald A. Depinho and Ziding Feng and Paul D Lampe and Samir M Hanash},
  journal={Cancer prevention research},
  volume={8 11},
Blood-based biomarkers for early detection of colorectal cancer could complement current approaches to colorectal cancer screening. We previously identified the APC-binding protein MAPRE1 as a potential colorectal cancer biomarker. Here, we undertook a case-control validation study to determine the performance of MAPRE1 in detecting early colorectal cancer and colon adenoma and to assess the potential relevance of additional biomarker candidates. We analyzed plasma samples from 60 patients with… CONTINUE READING
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