MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.

@article{Voncken2005MAPKAPK3,
  title={MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.},
  author={Jan Willem Voncken and Hanneke Niessen and Bernd Neufeld and Ulrike E.E. Rennefahrt and Vivian E. H. Dahlmans and Nard Kubben and Barbara Holzer and Stephan Ludwig and Ulf R{\"u}diger Rapp},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 7},
  pages={5178-87}
}
Polycomb group (PcG) proteins form chromatin-associated, transcriptionally repressive complexes, which are critically involved in the control of cell proliferation and differentiation. Although the mechanisms involved in PcG-mediated repression are beginning to unravel, little is known about the regulation of PcG function. We showed previously that PcG complexes are phosphorylated in vivo, which regulates their association with chromatin. The nature of the responsible PcG kinases remained… CONTINUE READING

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