MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway.

@article{Zhao2015MAPK1UT,
  title={MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway.},
  author={Jing Zhao and Li Li and Ling Peng},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 12},
  pages={15947-53}
}
The previous studies identify mammalian heart is terminal differentiation organs without regenerative capacity. Recently, there is some evidence point that cardiomyocytes are not terminally differentiated cells and cell proliferation may be stimulated in the pathologic heart. The aim of this study is to discover the possible mechanism which involved in cardiomyocytes proliferation process. In this study, the proliferation assay and cell cycle assay showed the proliferation of cardiomyocytes was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook

  • A Germani, G Di Rocco, F Limana, F Martelli, MC. Capogrossi
  • Trends Mol Med
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…