MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening

@inproceedings{Farhan2010MAPKST,
  title={MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening},
  author={Hesso Farhan and Markus W. Wendeler and Sandra Mitrovic and Eugenio Fava and Yael Silberberg and Roded Sharan and Marino Zerial and H P Hauri},
  booktitle={The Journal of cell biology},
  year={2010}
}
To what extent the secretory pathway is regulated by cellular signaling is unknown. In this study, we used RNA interference to explore the function of human kinases and phosphatases in controlling the organization of and trafficking within the secretory pathway. We identified 122 kinases/phosphatases that affect endoplasmic reticulum (ER) export, ER exit sites (ERESs), and/or the Golgi apparatus. Numerous kinases/phosphatases regulate the number of ERESs and ER to Golgi protein trafficking… CONTINUE READING