MAPK signaling is necessary for neurogenesis in Nematostella vectensis

@inproceedings{Layden2016MAPKSI,
  title={MAPK signaling is necessary for neurogenesis in Nematostella vectensis},
  author={Michael J. Layden and Hereroa Johnston and Aldine R Amiel and Jamie Ann Havrilak and Bailey M Steinworth and Taylor Mei Hop Chock and Eric R{\"o}ttinger and Mark Q. Martindale},
  booktitle={BMC Biology},
  year={2016}
}
BackgroundThe nerve net of Nematostella is generated using a conserved cascade of neurogenic transcription factors. For example, NvashA, a homolog of the achaete-scute family of basic helix-loop-helix transcription factors, is necessary and sufficient to specify a subset of embryonic neurons. However, positive regulators required for the expression of neurogenic transcription factors remain poorly understood.ResultsWe show that treatment with the MEK/MAPK inhibitor U0126 severely reduces the… CONTINUE READING
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