MAPK signal transduction pathway mediates agrin effects on neurite elongation in cultured hippocampal neurons.

@article{Karasewski2003MAPKST,
  title={MAPK signal transduction pathway mediates agrin effects on neurite elongation in cultured hippocampal neurons.},
  author={Lisa Karasewski and Adriana Carolina Marques Ferreira},
  journal={Journal of neurobiology},
  year={2003},
  volume={55 1},
  pages={
          14-24
        }
}
We have previously shown that agrin regulates the rates of axonal and dendritic elongation by modulating the expression of microtubule-associated proteins in cultured hippocampal neurons. However, the mechanisms by which agrin-induced signals are propagated to the nucleus where they can lead to the phosphorylation, and hence the activation, of transcription factors, are not known. In the present study, we identified downstream elements that play essential roles in the agrin-signaling pathway in… CONTINUE READING