MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells.

@article{Romashko2003MAPKPM,
  title={MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells.},
  author={John Romashko and Stuart Horowitz and William R. Franek and Tom Palaia and Edmund J Miller and Anning Lin and Michael J. Birrer and William Scott and Lin L. Mantell},
  journal={Free radical biology & medicine},
  year={2003},
  volume={35 8},
  pages={978-93}
}
Cell injury and cell death of pulmonary epithelium plays an important role in the pathogenesis of acute lung injury in animals exposed to prolonged hyperoxia. The aim of this study was to decipher the molecular mechanisms modulating cell death induced by hyperoxia in lung epithelium. Cell death is thought to be either apoptotic, with shrinking phenotypes and activated caspases, or oncotic, with swelling organelles. Exposure to 95% O2 (hyperoxia) induced cell death of MLE-12 cells with cellular… CONTINUE READING