MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.

@article{Li2007MAPKPM,
  title={MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.},
  author={Chaojun Li and Wen Ning and Michael A. Matthay and Carol Feghali-Bostwick and Augustine M. K. Choi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={292 5},
  pages={L1297-303}
}
Cigarette smoking, a major risk factor for chronic obstructive pulmonary disease, can cause airway inflammation, airway narrowing, and loss of elasticity, leading to chronic airflow limitation. In this report, we sought to define the signaling pathways activated by smoke and to identify molecules responsible for cigarette smoke-induced inflammation. We applied cigarette smoke water extract (CSE) to primary human lung fibroblasts and found that CSE significantly increased CXC chemokine IL-8… CONTINUE READING
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