MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.


STAT1 (signal transducer and activator of transcription 1) is a critical mediator of IFN-gamma (interferon-gamma)-induced gene responses, and its function is regulated through phosphorylation of Tyr701 and Ser727. MAPK (mitogen-activated protein kinase) pathways mediate phosphorylation of Ser727 in response to microbial infections, stress stimuli and growth… (More)


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@article{Vanhatupa2008MAPKinducedSP, title={MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.}, author={Sari Vanhatupa and Daniela Ungureanu and Maija Paakkunainen and Olli Silvennoinen}, journal={The Biochemical journal}, year={2008}, volume={409 1}, pages={179-85} }