MAPK cascade signalling and synaptic plasticity

@article{Thomas2004MAPKCS,
  title={MAPK cascade signalling and synaptic plasticity},
  author={Gareth M. Thomas and Richard L. Huganir},
  journal={Nature Reviews Neuroscience},
  year={2004},
  volume={5},
  pages={173-183}
}
The mitogen-activated protein kinase (MAPK) cascade that leads to the activation of extracellular signal-regulated kinases-1 and -2 (ERK1 and ERK2) has a key role in the differentiation of some cell types and the proliferation of others. However, several recent reports implicate this cascade in the control of synaptic plasticity in the adult brain. ERK signalling seems to be essential for characterized neuronal transcriptional events, and might also regulate synaptic targets to control… 
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Extracellular-signal-regulated kinase signalling in neurons
The MAPK cascade is required for mammalian associative learning
TLDR
MAPK activation increased in the rat hippocampus after an associative learning task, contextual fear conditioning, and two other protein kinases known to be activated during hippocampal LTP, protein kinase C and α-calcium/calmodulinprotein kinase II, also were activated in the hippocampus after learning.
A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation*
TLDR
It is reported that the MAPK cascade is required for hippocampal long term potentiation (LTP), a robust and widely studied form of synaptic plasticity, and the first demonstration of a role for theMAPK cascade in the activity-dependent modification of synaptic connections between neurons in the adult mammalian nervous system.
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TLDR
It is demonstrated that p42 MAPK can be regulated in an activity-dependent manner in the hippocampus and identified it as a potential component of the LTP induction cascades in area CA1, suggesting that p 42 MAPK might be an important regulator of synaptic plasticity in post-mitotic neurons.
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TLDR
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TLDR
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TLDR
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