MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption.

@article{Singh2007MAPKAH,
  title={MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption.},
  author={Divyendu Singh and Kelly L. McCann and Farhad Imani},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 2},
  pages={
          L436-45
        }
}
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis in infants, and a common feature of RSV infections is increased lung permeability. The accumulation of fluid in the infected lungs is caused by changes in the endothelial and epithelial membrane integrity. However, the exact mechanisms of viral-induced fluid extravasation remain unclear. Here, we report that infection of human epithelial cells with RSV results in significant epithelial membrane barrier disruption as assessed… CONTINUE READING

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