MAPK activation determines renal epithelial cell survival during oxidative injury.

@article{Mari1999MAPKAD,
  title={MAPK activation determines renal epithelial cell survival during oxidative injury.},
  author={John F di Mari and Roger J Davis and Robert L. Safirstein},
  journal={American journal of physiology. Renal physiology},
  year={1999},
  volume={277 2},
  pages={F195-F203}
}
Ischemia/reperfusion (I/R) injury induces both functional and morphological changes in the kidney. Necrosis, predominantly of the proximal tubule (PT), is the hallmark of this model of renal injury, whereas cells of the distal nephron survive, apparently intact. We examined whether differences in cellular outcome of the various regions of the nephron may be due to segmental variation in the activation of the mitogen-activated protein kinases (MAPKs) in response to I/R injury. Whereas c-Jun N… CONTINUE READING
91 Extracted Citations
45 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 91 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 45 references

Safirstein. N-acetyl-cysteine ameliorates ischemic renal failure

  • J. F. Di Mari, J. Megyesi, N. Udvarhelyi, P. Price, R. Davis
  • Am. J. Physiol. 272 (Renal Physiol. 41):
  • 1997
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…