MAPK/ERK and Wnt/β-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells.

@article{Jin2011MAPKERKAW,
  title={MAPK/ERK and Wnt/β-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells.},
  author={Caixia Jin and Lisa J. Samuelson and Cai-Bin Cui and Yi Sun and David A Gerber},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={409 4},
  pages={
          803-7
        }
}
Hepatic progenitor cells (HPCs) persist in adulthood and have the potential to play a major role in regenerating diseased liver. However, the signaling pathways that both directly and indirectly regulate HPCs' self-renewal and differentiation remain elusive. Previously, we identified a bipotent, stem cell antigen-1 (Sca-1) positive HPC population from naïve adult liver tissue. In the present study, we aimed to investigate the involvement of various signaling pathways in Sca-1(+) HPC… CONTINUE READING

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