MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis

  title={MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis},
  author={Catarina P. Samora and Binyam Mogessie and Leslie C. Conway and Jennifer L. Ross and Anne Straube and Andrew D. McAinsh},
  journal={Nature Cell Biology},
Correct positioning of the mitotic spindle is critical to establish the correct cell-division plane. Spindle positioning involves capture of astral microtubules and generation of pushing/pulling forces at the cell cortex. Here we show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells. We propose that CLASP1 is required to correctly capture astral microtubules, whereas MAP4… 

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ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules

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