MAP3Ks as central regulators of cell fate during development

@article{Craig2008MAP3KsAC,
  title={MAP3Ks as central regulators of cell fate during development},
  author={Evisabel A. Craig and Mark V. Stevens and Richard R. Vaillancourt and Todd D Camenisch},
  journal={Developmental Dynamics},
  year={2008},
  volume={237}
}
The cytoplasmic serine/threonine kinases transduce extracellular signals into regulatory events that impact cellular responses. The induction of one kinase triggers the activation of several downstream kinases, leading to the regulation of transcription factors to affect gene function. This arrangement allows for the kinase cascade to be amplified, and integrated according to the cellular context. An upstream mitogen or growth factor signal initiates a module of three kinases: a mitogen… 

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This chapter focuses on defining the diverse mechanisms by which different MAPKs and their scaffolding proteins interact and the significance of such interactions in the regulation of specific cellular responses.

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It is found that overexpression of the wild-type kinases stimulated JNK signaling in alternate contexts, so cells were capable of responding to both MAP3Ks, but with distinct outcomes.

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Results of this work establish the S1PR-MAP3K1-JNK pathway as a crucial signaling mechanism for epithelial cell movement and morphogenesis.

Differential Roles of ASK1 and TAK1 in Helicobacter pylori-Induced Cellular Responses

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Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells

Novel APOBEC1 target 1 (Nat1) is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (Eif4g1) and ribosomal proteins, which show that Nat1 is involved in the translation of proteins that are required for cell differentiation.
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