MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.

  title={MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.},
  author={Amy N. Abell and Nicole Vincent Jordan and Weichun Huang and Aleix Prat and Alicia A. Midland and Nancy Lassignal Johnson and Deborah A. Granger and Piotr A. Mieczkowski and Charles M. Perou and Shawn M. Gomez and LePing Li and Gary Leon Johnson},
  journal={Cell stem cell},
  volume={8 5},
Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epithelial-mesenchymal transition (EMT). Here, we show that MAP3K4 controls the activity of the histone acetyltransferase CBP, and that acetylation of histones H2A and H2B by CBP is required to maintain the… CONTINUE READING
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