MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

@article{Malinin1997MAP3KrelatedKI,
  title={MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1},
  author={Nikolai L. Malinin and Mark P Boldin and Andrei V. Kovalenko and David Wallach},
  journal={Nature},
  year={1997},
  volume={385},
  pages={540-544}
}
Several members of the tumour-necrosis/nerve-growth factor (TNF/NGF) receptor family activate the transcription factor NF-KB through a common adaptor protein, Traf2 (refs 1–5), whereas the interleukin 1 type-I receptor activates NF-KB independently of Traf2 (ref. 4). We have now cloned a new protein kinase, NIK, which binds to Traf2 and stimulates NF-KB activity. This kinase shares sequence similarity with several MAPKK kinases. Expression in cells of kinase-deficient NIK mutants fails to… CONTINUE READING
Highly Influential
This paper has highly influenced 24 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
326 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 326 extracted citations

Similar Papers

Loading similar papers…