MAP kinases in immune responses.

  title={MAP kinases in immune responses.},
  author={Yong Liang Zhang and Chen Dong},
  journal={Cellular & molecular immunology},
  volume={2 1},
MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune responses. There are three main families of MAPKs in mammals. Each of them has its own activators, inactivators, substrates and scaffolds, which altogether form a fine signaling network in response to different extracellular or intracellular stimulation. In this review, we summarize recent advances in understanding of the regulation of MAP… CONTINUE READING

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