MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells.

@article{Shen2006MAPKR,
  title={MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells.},
  author={Qin Shen and Ran Zhang and Narayan R. Bhat},
  journal={Brain research},
  year={2006},
  volume={1086 1},
  pages={9-16}
}
Interferongamma inducible protein-10 (IP10 or CXCL10), a Th-1 affiliated chemokine, is expressed by activated glial cells and may contribute to the trafficking of immune cells in the inflamed central nervous system. This study examines the regulation of the expression of this chemokine in cultured microglial cells focusing on the roles of mitogen-activated protein (MAP) kinase cascades. Exposure of a mouse microglial cell line, BV-2, to lipopolysaccharide (LPS) and IFNgamma led to an induction… CONTINUE READING

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