MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

@article{Zhao2006MAPKP,
  title={MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock},
  author={Qun Li Zhao and Xianxi Wang and L D Nelin and Yongxue Yao and R. A. Da Matta and Mary E. Manson and Reshma S. Baliga and Xiaomei Meng and Charles V. Smith and John Anthony Bauer and Cheong-Hee Chang and Yusen Liu},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={131 - 140}
}
Septic shock is a leading cause of morbidity and mortality. However, genetic factors predisposing to septic shock are not fully understood. Excessive production of proinflammatory cytokines, particularly tumor necrosis factor (TNF)-alpha, and the resultant severe hypotension play a central role in the pathophysiological process. Mitogen-activated protein (MAP) kinase cascades are crucial in the biosynthesis of proinflammatory cytokines. MAP kinase phosphatase (MKP)-1 is an archetypal member of… CONTINUE READING
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