MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula.

@article{Chtel2011MAPKC,
  title={MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula.},
  author={Am{\'e}lie Ch{\^a}tel and H{\'e}l{\`e}ne Talarmin and Bojan Hamer and Heinz C. Schr{\"o}der and Werner E G M{\"u}ller and Germaine Dorange},
  journal={Ecotoxicology},
  year={2011},
  volume={20 8},
  pages={1727-40}
}
In the present study, we analyzed the effects of two major pollutants of the environment, tributyltin (TBT) and water-accommodated fraction (WAF) of diesel oil, on MAP kinase activation, apoptosis induction and DNA damage, in the marine sponge Suberites domuncula. Our results clearly demonstrated a differential activation of the MAPKs depending on the chemicals tested. TBT induced the activation of p38 and JNK while diesel oil enhanced activation of both ERK and p38. The activation of MAPKs was… CONTINUE READING