MAP and Kinesin dependent nuclear positioning is required for skeletal muscle function

@inproceedings{Metzger2012MAPAK,
  title={MAP and Kinesin dependent nuclear positioning is required for skeletal muscle function},
  author={Thomas Metzger and Vincent Gache and Mu Xu and Bruno Cadot and Eric S Folker and Brian E. Richardson and Edgar R Gomes and Mary Baylies},
  booktitle={Nature},
  year={2012}
}
The basic unit of skeletal muscle in all metazoans is the multinucleate myofibre, within which individual nuclei are regularly positioned. The molecular machinery responsible for myonuclear positioning is not known. Improperly positioned nuclei are a hallmark of numerous diseases of muscle, including centronuclear myopathies, but it is unclear whether correct nuclear positioning is necessary for muscle function. Here we identify the microtubule-associated protein ensconsin (Ens)/microtubule… CONTINUE READING
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