MAP Kinase Signaling Cascade Dysfunction Specific to Alzheimer's Disease in Fibroblasts

@article{Zhao2002MAPKS,
  title={MAP Kinase Signaling Cascade Dysfunction Specific to Alzheimer's Disease in Fibroblasts},
  author={Wei-qin Zhao and Lakshmi Ravindranath and Ali Si Mohamed and O Even Zohar and Daniel L. Alkon},
  journal={Neurobiology of Disease},
  year={2002},
  volume={11},
  pages={166-183}
}
Mitogen-activated protein kinases (such as Erk1/2) regulate phosphorylation of the microtubule-associated protein tau and processing of the amyloid protein beta, both events critical to the pathophysiology of Alzheimer's disease (AD). Here we report that enhanced and prolonged Erk1/2 phosphorylation in response to bradykinin (BK) was detected in fibroblasts of both familial and sporadic AD, but not age-matched controls (AC). The AD-associated abnormality in Erk1/2 phosphorylation was not seen… CONTINUE READING

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