MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles

@inproceedings{Menzel2012MAPKinaseRC,
  title={MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles},
  author={Nicolas Menzel and Wolfgang Fischl and Kathrin Hueging and Dorothea Bankwitz and Anne Frentzen and Sibylle Haid and Juliane Gentzsch and Lars Kaderali and Ralf Bartenschlager and Thomas Pietschmann},
  booktitle={PLoS pathogens},
  year={2012}
}
Hepatitis C virus (HCV) has infected around 160 million individuals. Current therapies have limited efficacy and are fraught with side effects. To identify cellular HCV dependency factors, possible therapeutic targets, we manipulated signaling cascades with pathway-specific inhibitors. Using this approach we identified the MAPK/ERK regulated, cytosolic, calcium-dependent, group IVA phospholipase A2 (PLA2G4A) as a novel HCV dependency factor. Inhibition of PLA2G4A activity reduced core protein… CONTINUE READING

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