MAOIs to RIMAs in anaesthesia — a literature review

  title={MAOIs to RIMAs in anaesthesia — a literature review},
  author={S. Hill and K W Yau and James G. Whitwam},
Monoamine oxidase inhibitors (MAOIs) are widely accepted as effective antidepressants. Unfortunately their use has been limited by their capacity to potentiate dietary tyramine (the so called “cheese effect”) and their interaction with other drugs. The latter poses a particular problem for patients undergoing anaesthesia. Traditional advice has been to stop MAOI therapy 2 weeks prior to anaesthesia. With the advent of reversible, specific inhibitors of MAO-A (RIMAs) there is less potential for… Expand
Antidepressive treatment with monoamine oxidase inhibitors and the occurrence of intraoperative hemodynamic events: a retrospective observational cohort study.
It is suggested that there is no longer much justification to discontinue these MAOIs before surgery, with the considerable risk of compromising patients' psychiatric status. Expand
Psychotropic drugs and the perioperative period: a proposal for a guideline in elective surgery.
Both the physical and psychiatric risks of patients who use antipsychotics and other antidepressants should be regarded as enhanced and patients on SSRIs with higher physical or psychiatric risks should be seen in consultation. Expand
Complications liées à l’utilisation périopératoire des médicaments antidépresseurs
La pratique clinique a permis de demystifier le risque de complications liees aux interferences potentielles des ATD avec les medicaments utilises en anesthesie and en reanimation. Expand
Update on canine demodicosis.
  • K. Gortel
  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 2006


Monoamine oxidase inhibitors and anaesthesia. A review.
There has been a recent renewal of interest in the use of monoamine oxidase inhibitors in psychiatry, and the interaction with pethidine has two distinct forms-"excitatory" and "depressive". Expand
monoamine oxidase inhibitors revisited
A final decision on the administration of anaesthesia in the presence of MAOI therapy can only be made by an anaesthetist familiar with the pharmacology of the MAO system and its inhibitors. Expand
Monoamine Oxidase Inhibitors in General Anesthesia: A Reevaluation.
Based on pharmacological data, a review of the literature, and these preliminary results, the recommended 2-week discontinuation of MAOI before ECT appears unwarranted. Expand
Monoamine Oxidase Inhibitors: Should They Be Discontinued Preoperatively?
It is concluded that discontinuing chronic MAOI therapy prior to anesthesia and surgery is not necessary and blood pressure and heart rate increases after ECT, but returned to baseline levels within 15 min. Expand
Antidepressant drug therapy: associated risks.
It is concluded that the new reversible MAOI antidepressant moclobemide is similar to other antidepressants in terms of efficacy but very noticeably superior in Terms of tolerance and safety. Expand
Effect of nonselective and selective inhibitors of monoamine oxidases A and B on pethidine toxicity in mice
The results indicate that both MAO A and MAO B need to be inhibited to increase pethidine toxicity and brain 5‐HT levels, and support the involvement of 5‐ HT in the toxic interaction between pETHidine andMAO inhibitors. Expand
Comparison of the effects of morphine, pethidine and pentazocine in rabbits pretreated with a monoamine oxidase inhibitor.
Morphine and pentazocine in doses of 1 mg and 10 mg/kg did not significantly alter the rectal temperature of rabbits pretreated with pargyline except for one rabbit which developed a delayed hyperthermia following the injection of morphine 1mg/kg. Expand
New Drugs for Depression
The B.S. 1619 can abolish all confusion in insulin dose-card reading, particularly by patients with poor eyesight, and the present unsatisfactory state of the insulin syringe is to be replaced. Expand
Low Serum Pseudocholinesterase Levels Complicating Treatment with Phenelzine
Investigations showed that the serum pseudocholinesterase levels returned to normal after withdrawal of phenelzine in four patients undergoing treatment with phenelZine, and in three cases after modified electric convulsion therapy. Expand
Potentiation of Pethidine
The introduction of the new style of women's shoes, nicknamed " winkle-picker " because of its sharp point, has been responsible for this lesion becoming more prevalent. Expand