MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy

  title={MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy},
  author={A. Reif and Jan F. Richter and Benjamin Straube and Michael Hoefler and Ulrike Lueken and Andrew T Gloster and Heike Weber and Katharina Domschke and Lydia Fehm and Andreas Str{\"o}hle and Andreas Jansen and Alexander L. Gerlach and Martin Pyka and Isabelle Reinhardt and Carsten Konrad and Andr{\'e} Wittmann and Bettina Pfleiderer and Georg W. Alpers and Paul Pauli and Thomas R. Lang and Volker Arolt and Hans-Ulrich Wittchen and Alfons Hamm and Tilo Kircher and J{\"u}rgen Deckert},
  journal={Molecular Psychiatry},
Panic disorder with agoraphobia (PD/AG) is a prevalent mental disorder featuring a substantial complex genetic component. At present, only a few established risk genes exist. Among these, the gene encoding monoamine oxidase A (MAOA) is noteworthy given that genetic variation has been demonstrated to influence gene expression and monoamine levels. Long alleles of the MAOA-uVNTR promoter polymorphism are associated with PD/AG and correspond with increased enzyme activity. Here, we have thus… CONTINUE READING
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