MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

@article{Mallajosyula2008MAOBEI,
  title={MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology},
  author={Jyothi Mallajosyula and Deepinder Kaur and Shankar J Chinta and Subramanian Rajagopalan and Anand Rane and David G. Nicholls and Donato A. Di Monte and Heather Macarthur and Julie K Andersen},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={439 - 456}
}
Age-related increases in monoamine oxidase B (MAO-B) may contribute to neurodegeneration associated with Parkinson's disease (PD). The MAO-B inhibitor deprenyl, a long-standing antiparkinsonian therapy, is currently used clinically in concert with the dopamine precursor L-DOPA. Clinical studies suggesting that deprenyl treatment alone is not protective against PD associated mortality were targeted to symptomatic patients. However, dopamine loss is at least 60% by the time PD is symptomatically… CONTINUE READING