Corpus ID: 58919041

MANGO SEEDS: A POTENTIAL SOURCE FOR THE ISOLATION OF BIOACTIVE COMPOUNDS WITH ANTI-CANCER ACTIVITY

@article{Timsina2015MANGOSA,
  title={MANGO SEEDS: A POTENTIAL SOURCE FOR THE ISOLATION OF BIOACTIVE COMPOUNDS WITH ANTI-CANCER ACTIVITY},
  author={Bibechana Sharma Timsina and Varalakshmi Kilingar Nadumane},
  journal={International Journal of Pharmacy and Pharmaceutical Sciences},
  year={2015},
  volume={7},
  pages={89-95}
}
  • B. Timsina, V. Nadumane
  • Published 2 May 2015
  • Biology
  • International Journal of Pharmacy and Pharmaceutical Sciences
Objective : The mango ( Mangifera indica L.), is a fruit with high levels of phytochemicals and the seeds have antioxidant, anti-inflammatory and anti-obesity effects. This study aims at the extraction of metabolites from mango seeds and evaluation of the antiproliferative properties on cancer cell lines. Methods : The antiproliferative effects of the ethanol extract of mango seeds were evaluated on the cancer cell line HeLa, CHO cell lines and also on normal human lymphocytes by MTT assay. The… Expand

Figures and Tables from this paper

Supercritical antisolvent fractionation as a tool for enhancing antiproliferative activity of mango seed kernel extracts against colon cancer cells
Abstract Mango seed kernel (MSK) has demonstrated to be a valuable source of bioactive phenolic compounds with antiproliferative activity against colon cancer cell lines. In this work, a phenolic MSKExpand
An integrated approach for the valorization of mango seed kernel: Efficient extraction solvent selection, phytochemical profiling and antiproliferative activity assessment.
TLDR
The obtained MSK-extract exhibited higher antiproliferative activity against human colon adenocarcinoma cell line HT-29 compared to traditional extraction procedures described in literature for MSK utilization, demonstrating the great potential of the proposed valorization strategy as a valuable opportunity for mango processing industry to deliver a value-added product to the market with health promoting properties. Expand
Bioactive Phenolic Compounds from the Agroindustrial Waste of Colombian Mango Cultivars ‘Sugar Mango’ and ‘Tommy Atkins’—An Alternative for Their Use and Valorization
TLDR
‘sugar mango’ waste may be considered a source of bioactive phenolics, with promising uses in food and pharmaceutical products, and a suitable alternative for the use and valorization of agroindustrial waste from Colombian mango cultivars is presented. Expand
Review on pharmacological activities of Mangifera indica and Zingiber officinale
TLDR
Ginger (Zingiber officinale) which belongs to the family of Zingiberaceae, has a long history of use in Chinese and Ayurvedic medicine as anantiemetic, anticoagulant, anti-inflammatory, pro-ageing, gastrointestinal, and antiarthritic activities. Expand
Pharmacological Activities of Mango (Mangifera Indica): A Review
TLDR
Mangoes (Mangifera indica) belong to genus Mangifera which consists of about 30 species of tropical fruiting trees in the flowering plant family Anacardiaceae and conquers the second position as a tropical crop, in terms of production. Expand
Redox Imbalance and Mitochondrial Release of Apoptogenic Factors at the Forefront of the Antitumor Action of Mango Peel Extract
TLDR
The analysis of the cytotoxic effects exerted by the different constituents of MPE allowed us to identify those phytochemicals responsible for the observed anticancer effects, sustaining their future employment as chemopreventive or therapeutic agents. Expand
Antibacterial Activity of Mangifera indica Leaves Aqueous and Alcoholic Extract
Antibacterial activities of aqueous and alcoholic extracts of Mangifera indica leaves were studied against pathogenic Streptococcus pyogens, Enterococcus faecalis and Escherichia coli bacterialExpand
Physicochemical characteristics, bioactive compounds and industrial applications of mango kernel and its products: A review.
TLDR
The nutritional profile of the kernel suggests its usability as a food ingredient in the development of value-added products such as mango kernel oil, mango Kernel butter, mango kernel flour, and biofilms among other diverse products. Expand
Anthony Cemaluk C Egbuonu and Gift E Ejike (2017). Effect of pulverized Mangifera indica (mango) seed kernel on monosodium glutamate-intoxicated rats’ serum antioxidant capacity, brain function and histology
Monosodium glutamate, a common food-flavoring additive, affects the brain and induces oxidative stress while the underutilized Mangifera indica L seed kernel (MSK) has phyto-medicinal values. ThisExpand
Profiling phenolic compounds in underutilized mango peel by-products from cultivars grown in Spanish subtropical climate over maturation course.
TLDR
Mango peels resulted to be a promising and low-cost resource of phenolic compounds to be exploited in food industry, but to enhance the nutraceutical value, factors such as cultivar and maturation degree should be taken into account. Expand
...
1
2
...

References

SHOWING 1-10 OF 40 REFERENCES
Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties.
TLDR
Overall, polyphenolics from several mango varieties exerted anticancer effects, where compounds from Haden and Ataulfo mango varieties possessed superior chemopreventive activity. Expand
A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines.
TLDR
Fraction 6 was shown in MDA-MB-435 cells to block cell cycle progression and induce cells to undergo apoptosis in a dose-dependent manner, and is potentially a source of a novel anticancer agent. Expand
SCREENING FOR ANTITUMOR AND ANTI-HIV ACTIVITIES OF NINE MEDICINAL PLANTS FROM ZAIRE
TLDR
In the AIDS-antiviral screen, the methanol extract from Jatropha curcas was found to produce a moderate cytoprotective effect against HIV in cultured human lymphoblastoid CEM-SS cells. Expand
Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts.
TLDR
Whole mango juice was effective in reducing the number of transformed foci in the neoplastic transformation assay in a dose-dependent manner, and these techniques provide valuable screening tools for health benefits derived from mango phytochemicals. Expand
Antioxidant and hepatoprotective activities of thai mango seed kernel extract.
TLDR
The hepatoprotective effect of MSKE is clearly supported by its polyphenolic nature of the main principle, PGG, which exhibited potent antioxidant and anti-inflammatory activities. Expand
Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship.
TLDR
Mangiferin showed hepatoprotective activity against carbon tetrachloride induced liver injury further supporting the free radical scavenging property in the in vivo system and naloxone revealed that plant extracts induced analgesia was independent of opioid receptor, whereas, mangiferin demonstrated significant interaction with it at peripheral site with a slight contribution at the neuronal level. Expand
Antioxidant and antiproliferative activities of strawberries.
TLDR
Overall, free phenolic content was weakly correlated with total antioxidant activity, and flavonoid and anthocyanin content did not correlate with total antioxidants activity. Expand
Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.).
TLDR
Mangiferin, detected at high concentrations in young leaves, in bark, and in old leaves (Itamaraka = 94 g/kg), shows an exceptionally strong antioxidant capacity. Expand
Induction of Apoptosis by Lupeol and Mango Extract in Mouse Prostate and LNCaP Cells
TLDR
Results of this study demonstrate that lupeol/MPE is effective in combating testosterone–induced changes in mouse prostate as well as causing apoptosis by modulating cell-growth regulators. Expand
Phenolic compounds and antioxidant capacity of Brazilian mango (Mangifera indica L.) varieties
Abstract Phenolic compounds and antioxidant activities of four mango varieties cultivated in Brazil were analyzed. The profile of flavonol- O -glycosides and xanthone- C -glycosides was characterizedExpand
...
1
2
3
4
...