MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma.

@article{SnchezIzquierdo2003MALT1ID,
  title={MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma.},
  author={Dolors S{\'a}nchez-Izquierdo and G{\'e}rard Buchonnet and Reiner Siebert and Randy D. Gascoyne and Joan Climent and Loraine Karran and Miguel Ruiz Mar{\'i}n and David Blesa and Douglas E. Horsman and Andreas Rosenwald and Louis M. Staudt and Donna Albertson and Ming-Qing Du and Hongtao Ye and Peter Marynen and Javier Garcia-conde and Dan Pinkel and Martin J. S. Dyer and Jos{\'e} {\'A}ngel Mart{\'i}nez-Climent},
  journal={Blood},
  year={2003},
  volume={101 11},
  pages={4539-46}
}
The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of mucosa-associated lymphoid tissue (MALT) lymphoma. Here, we show that deregulated MALT1 expression may occur in B-cell non-Hodgkin lymphoma (B-NHL) of various histologic subtypes either through translocation to the immunoglobulin heavy chain (IGH) locus or by genomic amplification. First, 2 cases, one case of MALT lymphoma and another of aggressive marginal zone lymphoma (MZL) with t(14;18)(q32… CONTINUE READING
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