MALT1 is an intrinsic regulator of regulatory T cells

  title={MALT1 is an intrinsic regulator of regulatory T cells},
  author={Anne Br{\"u}stle and Dirk H{\"a}ussinger Brenner and Christiane B. Knobbe-Thomsen and Michael J Cox and Philipp A. Lang and Karl S Lang and Tak W Mak},
  booktitle={Cell Death and Differentiation},
Regulatory T cells (Tregs) are crucial for the maintenance of immunological self-tolerance and their absence or dysfunction can lead to autoimmunity. However, the molecular pathways that govern Treg biology remain obscure. In this study, we show that the nuclear factor-κB signalling mediator mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an important novel regulator of both Tregs originating in the thymus (‘natural’ or nTregs) and Tregs induced to differentiate… CONTINUE READING
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