MALDI mass spectrometry imaging: A cutting-edge tool for fundamental and clinical histopathology.

  title={MALDI mass spectrometry imaging: A cutting-edge tool for fundamental and clinical histopathology.},
  author={R{\'e}mi Longuesp{\'e}e and Rita Casadonte and Mark Kriegsmann and Charles Pottier and Ga{\"e}l Picard de Muller and Philippe O Delvenne and J{\"o}rg Kriegsmann and Edwin De Pauw},
  journal={Proteomics. Clinical applications},
  volume={10 7},
Histopathological diagnoses have been done in the last century based on hematoxylin and eosin staining. These methods were complemented by histochemistry, electron microscopy, immunohistochemistry (IHC), and molecular techniques. Mass spectrometry (MS) methods allow the thorough examination of various biocompounds in extracts and tissue sections. Today, mass spectrometry imaging (MSI), and especially matrix-assisted laser desorption ionization (MALDI) imaging links classical histology and… CONTINUE READING
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