MALDI-MS drug analysis in biological samples: opportunities and challenges.

@article{Steuer2016MALDIMSDA,
  title={MALDI-MS drug analysis in biological samples: opportunities and challenges.},
  author={Andrea E Steuer and Michael Poetzsch and Thomas Kraemer},
  journal={Bioanalysis},
  year={2016},
  volume={8 17},
  pages={1859-78}
}
Drug analysis represents a large field in different disciplines. Plasma is commonly considered to be the biosample of choice for that purpose. However, concentrations often do not represent the levels present within deeper compartments and therefore cannot sufficiently explain efficacy or toxicology of drugs. MALDI-MS in drug analysis is of great interest for high-throughput quantification and particularly spatially resolved tissue imaging. The current perspective article will deal with… CONTINUE READING