MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain.

Abstract

The transcription factor serum response factor (SRF) interacts with its cofactor, MAL/MKL1, a member of the myocardin-related transcription factor (MRTF) family, through its DNA-binding domain. We define a seven-residue sequence within the conserved MAL B1 region essential and sufficient for complex formation. The neighboring Q-box sequence facilitates this… (More)

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